Farhan Chowdhury | Mechanical Engineering and Energy Processes | SIU

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College of Engineering

Farhan Chowdhury

Assistant Professor

Farhan Chowdhury

Office: ENGR B120
Phone: 618-453-7833
Fax: 618-453-7658
farhan.chowdhury@siu.edu

Dr. Farhan Chowdhury is an Assistant Professor in the Department of Mechanical Engineering and Energy Processes. His research is in the area of Mechanobiology

Webpages: Lab website, Google Scholar

EDUCATION

Ph.D., Mechanical Engineering, University of Illinois at Urbana-Champaign, 2011
Postdoctoral Fellow, Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign

RESEARCH

The overall objective of our research program is to advance fundamental understanding of mechanotransduction processes in single living cells with single molecule precision. Our transformative research, at the interface of engineering, biology, and single molecule physics, primarily focuses to address the outstanding questions in stem cells and cancer mechanobiology. Specifically, we utilize tension gauge tethers (TGTs), FRET biosensors, smFISH, and high throughput next generation sequencing techniques to thoroughly investigate outside-in and inside-out signaling in living cells. Our integrated approach enables us to measure dynamic changes occurring at single molecule level under specific mechanical microenvironments. Furthermore, we are driven to translate this knowledge to clinics to improve quality of life.

Click here to find more about our Mechanobiology Lab

TEACHING

BME 539: Biomechanics I

SELECTED PUBLICATIONS

  1. F Chowdhury, ITS Li, BJ Leslie, S Doğanay, R Singh, X Wang, J Seong et al., “Single molecular force across single integrins dictates cell spreading,” Integrative Biology 7 (10), 1265-1271, 2015
  2. F Chowdhury, S Na, D Li, YC Poh, TS Tanaka, F Wang, N Wang, “Material properties of the cell dictate stress-induced spreading and differentiation in embryonic stem cells,” Nature Materials 9 (1), 82-88, 2010
  3. F Chowdhury, Y Li, YC Poh, T Yokohama-Tamaki, N Wang, TS Tanaka, “Soft substrates promote homogeneous self-renewal of embryonic stem cells via downregulating cell-matrix tractions,” PloS ONE 5 (12), e15655, 2010
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